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Early Neutrophil-to-Lymphocyte Ratio Is a Prognostic Marker in Acute Ischemic Stroke After Successful Revascularization.
Zou, Feihui; Wang, Jian; Han, Bin; Bao, Jiannan; Fu, Yin; Liu, Kefeng.
Affiliation
  • Zou F; Department of Neurosurgery, Changzhou Second People's Hospital Affiliated to Nanjing Medical University, Jiangsu, Changzhou, China.
  • Wang J; Department of Neurosurgery, Changzhou Second People's Hospital Affiliated to Nanjing Medical University, Jiangsu, Changzhou, China.
  • Han B; Department of Neurosurgery, Changzhou Second People's Hospital Affiliated to Nanjing Medical University, Jiangsu, Changzhou, China.
  • Bao J; Department of Neurosurgery, Changzhou Second People's Hospital Affiliated to Nanjing Medical University, Jiangsu, Changzhou, China.
  • Fu Y; Department of Neurosurgery, Changzhou Second People's Hospital Affiliated to Nanjing Medical University, Jiangsu, Changzhou, China.
  • Liu K; Department of Neurosurgery, Changzhou Second People's Hospital Affiliated to Nanjing Medical University, Jiangsu, Changzhou, China. Electronic address: liu1438@163.com.
World Neurosurg ; 157: e401-e409, 2022 01.
Article in En | MEDLINE | ID: mdl-34662658
OBJECTIVE: To explore the association between early neutrophil-to-lymphocyte ratio (ENLR) and prognosis of anterior circulation large-vessel occlusion stroke (LVOS) after patients undergo endovascular treatment (EVT) with successful revascularization. METHODS: Patients who experienced acute anterior circulation LVOS and underwent EVT at Changzhou Second People's Hospital Affiliated to Nanjing Medical University between May 2017 and May 2020 were included in this retrospective study. We collected information about patients' baseline characteristics, medical history, laboratory test results, imaging data, and endovascular treatment outcomes, as well as data from follow-up at 3 months. Univariate and multivariate logistic regression models were used to evaluate the association between ENLR and functional disease prognosis. A piecewise linear regression model was also applied to compute the threshold effect of ENLR on poor prognosis (defined as modified Rankin Scale score 3-6) at 3 months using a smoothing plot. RESULTS: Of 224 patients who received EVT during the study period, 160 patients were included in the analysis. After adjustments were made for potential confounders, multivariate analysis demonstrated a significant association between ENLR and poor prognosis at 3 months (odds radio 1.19; 95% confidence interval 1.07-1.32; P = 0.0016). An ENLR ≥9.75 was found to be significantly associated with poor prognosis at 3 months (odds ratio 1.54; 95% confidence interval 1.19-2.00; P = 0.0119). CONCLUSIONS: Increased ENLR after successful revascularization is independently associated with poor prognosis. These findings suggest that ENLR could be used to inform treatment strategies for patients who experience anterior circulation LVOS.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lymphocytes / Brain Ischemia / Cerebral Revascularization / Endovascular Procedures / Ischemic Stroke / Neutrophils Type of study: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: World Neurosurg Journal subject: NEUROCIRURGIA Year: 2022 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lymphocytes / Brain Ischemia / Cerebral Revascularization / Endovascular Procedures / Ischemic Stroke / Neutrophils Type of study: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: World Neurosurg Journal subject: NEUROCIRURGIA Year: 2022 Document type: Article Affiliation country: Country of publication: